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Literature summary for 3.4.22.36 extracted from

  • Hara, H.; Tsuchiya, K.; Nomura, T.; Kawamura, I.; Shoma, S.; Mitsuyama, M.
    Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm (2008), J. Immunol., 180, 7859-7868.
    View publication on PubMed
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of caspase-1 is induced in macrophages by Listeria monocytogenes infection depending on cytolysin and listeriolysin O, after evasion from phagosome into the cytoplasm, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-benzyloxycarbonyl-Tyr-Val-Ala-Asp-fluoromethyl ketone
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Mus musculus activation of caspase-1 as a key event resulting in interleukin-18 production, caspase-1 is essential for interleukin-18 production in infected macrophages interleukin-18 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 female C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage wild-type and TLR4 knockout macrophage Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-18 + H2O
-
 Mus musculus interleukin-18 + ?
-
 ?
pro-interleukin-18 + H2O activation of caspase-1 as a key event resulting in interleukin-18 production, caspase-1 is essential for interleukin-18 production in infected macrophages Mus musculus interleukin-18 + ?
-
 ?