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Literature summary for 3.4.22.36 extracted from

  • Case, C.L.; Shin, S.; Roy, C.R.
    Asc and Ipaf inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila (2009), Infect. Immun., 17, 1981-1991.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
adapter protein Asc is important for caspase-1 activation during Legionella pneumophila infection, mechanism, overview. Activation of caspase-1 through Asc does not require the flagellin-sensing pathway involving the host nucleotide-binding domain and leucine-rich repeat-containing protein Ipaf, NLRC4. Asc-dependent caspase-1 activation is inhibited by high extracellular potassium levels Mus musculus
Ipaf i.e. host nucleotide-binding domain and leucine-rich repeatcontaining protein Ipaf or NLRC4, Ipaf-dependent activation is unaffected by potassium treatment Mus musculus
additional information activation of caspase-1 in macrophages occurs independently of Nalp3 and proteasome activity Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ high extracellular K+ levels inhibit Asc-dependent caspase-1 activation, whereas Ipaf-dependent activation was unaffected by potassium treatment Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins ?
-
 ?
additional information Mus musculus C57BL/6 caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins ?
-
 ?
pro-interleukin-18 + H2O Mus musculus
-
 mature interleukin-18
-
 ?
pro-interleukin-18 + H2O Mus musculus C57BL/6
-
 mature interleukin-18
-
 ?
pro-interleukin-1beta + H2O Mus musculus
-
 mature interleukin-1beta
-
 ?
pro-interleukin-1beta + H2O Mus musculus C57BL/6
-
 mature interleukin-1beta
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins Mus musculus ?
-
 ?
additional information caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins Mus musculus C57BL/6 ?
-
 ?
pro-interleukin-18 + H2O
-
 Mus musculus mature interleukin-18
-
 ?
pro-interleukin-18 + H2O
-
 Mus musculus C57BL/6 mature interleukin-18
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus mature interleukin-1beta
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus C57BL/6 mature interleukin-1beta
-
 ?