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Literature summary for 3.4.22.36 extracted from

  • Levin, T.C.; Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
    Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin (2008), Cell. Microbiol., 10, 2434-2446.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information nigericin-induces caspase-1 activation. Nalp1b or NLRP1b inflammasome-mediated activation of caspase-1 by anthrax lethal toxin, prevented by heat shock, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information heat shock inhibits caspase-1 activity while also preventing its Nalp1b or NLRP1b inflammasome-mediated or nigericin-induced activation by anthrax lethal toxin, but once caspase-1 activation is initiated, heat shock is ineffective, time dependence, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Mus musculus
-
 mature interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O Mus musculus BALB/cJ
-
 mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 BALB/cJ mice
-
Mus musculus BALB/cJ
-
 BALB/cJ mice
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Mus musculus
-
macrophage bone marrow-derived macrophage, BMDM cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
 Mus musculus mature interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O caspase-1 effectively cleaves interleukin-1beta to its mature form in both heat shock and 37°C conditions Mus musculus mature interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus BALB/cJ mature interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O caspase-1 effectively cleaves interleukin-1beta to its mature form in both heat shock and 37°C conditions Mus musculus BALB/cJ mature interleukin-1beta + ?
-
 ?