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Literature summary for 3.4.22.36 extracted from

  • Chae, J.J.; Wood, G.; Richard, K.; Jaffe, H.; Colburn, N.T.; Masters, S.L.; Gumucio, D.L.; Shoham, N.G.; Kastner, D.L.
    The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment (2008), Blood, 112, 1794-1803.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
co-expression of caspase-1 with wild-type and mutant, myc-tagged B30.2 domain-deleted pyrin, in PT67 cells, co-expression of wild-type pyrin, caspase-1, and interleukin-1beta in COS-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-Trp-Glu-His-Asp-fluoromethylketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens pyrin and caspase-1 interact in their pathway for NF-kappaB activation, mechanism and regulation, overview ?
-
 ?
pyrin + H2O Homo sapiens caspase-1 cleaves pyrin at Asp330, Familial Mediterranean fever-associated mutants are cleaved more than wild-type pyrin by caspase-1. Pyrin itself regulates caspase-1 activation and interleukin-1beta production through interaction of its N-terminal PYD motif with the ASC adapterprotein, and also modulates interleukin-1beta production by interaction of its C-terminal B30.2 domain with the catalytic domains of caspase-1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pyrin and caspase-1 interact in their pathway for NF-kappaB activation, mechanism and regulation, overview Homo sapiens ?
-
 ?
pyrin + H2O caspase-1 cleaves pyrin at Asp330, Familial Mediterranean fever-associated mutants are cleaved more than wild-type pyrin by caspase-1. Pyrin itself regulates caspase-1 activation and interleukin-1beta production through interaction of its N-terminal PYD motif with the ASC adapterprotein, and also modulates interleukin-1beta production by interaction of its C-terminal B30.2 domain with the catalytic domains of caspase-1 Homo sapiens ?
-
 ?
pyrin + H2O recombinant substrate expressed in PT67 cells Homo sapiens ?
-
 ?