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Literature summary for 3.4.22.36 extracted from

  • Ahmad, M.; Srinivasula, S.M.; Wang, L.; Litwack, G.; Fernandes-Alnemric, T.; Alnemri, E.S.
    Sppdoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35 (1997), J. Biol. Chem., 272, 1421-1424.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Spodoptera frugiperda

Inhibitors

Inhibitors Comment Organism Structure
p35 IC50: 0.5 nM Spodoptera frugiperda

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Spodoptera frugiperda the enzyme is able to induce apoptosis in Sf9 cells ?
-
 ?
nuclear immunophilin FKBP46 + H2O Spodoptera frugiperda
-
 ?
-
 ?
p35 + H2O Spodoptera frugiperda cleavage at Asp87 100000 Da fragment + 25000 Da fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Spodoptera frugiperda P89116
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the proenzyme of Sf caspase-1 is 299 amino acids in length and can undergo autocatalytic processing in Escherichia coli to an active enzyme heterocomplex. Autoprocessing occurs at Asp28-, Asp184, and Asp95 to generate the large p19/p18 and the small p12 subunits Spodoptera frugiperda

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is able to induce apoptosis in Sf9 cells Spodoptera frugiperda ?
-
 ?
nuclear immunophilin FKBP46 + H2O
-
 Spodoptera frugiperda ?
-
 ?
p35 + H2O cleavage at Asp87 Spodoptera frugiperda 100000 Da fragment + 25000 Da fragment
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000005
-
 IC50: 0.5 nM Spodoptera frugiperda p35