Literature summary for 3.4.22.34 extracted from

Hartmann, D.; Sima, R.; Konvickova, J.; Perner, J.; Kopacek, P.; Sojka, D.
Multiple legumain isoenzymes in ticks (2018), Int. J. Parasitol., 48, 167-178 .

Search for more literature for 3.4.22.34

Cloned(Commentary)

Cloned (Comment)	Organism
-	Ixodes scapularis

Organism

Organism	UniProt	Comment	Textmining
Ixodes scapularis	-	-	-
Ixodes scapularis	A0A1S6XZC8	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	IsAE2 harbors three N-glycosylation sites	Ixodes scapularis

Source Tissue

Source Tissue	Comment	Organism	Textmining
egg	-	Ixodes scapularis	-
gut	exclusively expressed in the gut tissue. IsAE1 is the principle legumain transcript in partially engorged females, and demonstrates its strong regulation by on-host feeding in larvae, nymphs and females. IsAE1 is the most highly expressed gut-specific legumain in blood fed ticks where it predominated over all its paralogues	Ixodes scapularis	-
gut	IsAE2 is the predominant gut legumain in unfed nymphs, unfed females and males	Ixodes scapularis	-

Synonyms

Synonyms	Comment	Organism
isae1	-	Ixodes scapularis
isae2	-	Ixodes scapularis

Expression

Organism	Comment	Expression
Ixodes scapularis	IsAE1 expression was strongly upregulated by feeding when the mRNA levels in unfed and fully fed samples are compared. However, IsAE1 mRNA is also detectable at relatively high levels in unfed larvae, almost comparable with fully fed females	up

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Release 2023.1 (January 2023)