Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | lysosomes of renal proximal tubular cells | Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | role in extracellular matrix remodeling via degradation of fibronectin indicated | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O89017 | 14-week-old male C57BL/6J wild-type and legumain-deficient mice analyzed | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | protein from kidney tissues used for western blot analysis, unilateral ureteral obstruction in legumain-deficient mice | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
assay of legumain activity described, fibronectin degradation by legumain shown, enhanced fibronectin processing by overexpression of legumain indicated, experimental design of unilateral ureteral obstruction reveals increased protein accumulation of fibronectin in the renal interstitial area in kidneys from legumain-deficient mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O | effect of legumain on fibronectin degradation analyzed, role of legumain in control of extracellular matrix turnover determined | Mus musculus | benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin | - |
? | |
additional information | role in extracellular matrix remodeling via degradation of fibronectin indicated | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AEP | - |
Mus musculus |
asparagine endopeptidase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay of legumain activity at | Mus musculus |