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Literature summary for 3.4.22.34 extracted from

  • Morita, Y.; Araki, H.; Sugimoto, T.; Takeuchi, K.; Yamane, T.; Maeda, T.; Yamamoto, Y.; Nishi, K.; Asano, M.; Shirahama-Noda, K.; Nishimura, M.; Uzu, T.; Hara-Nishimura, I.; Koya, D.; Kashiwagi, A.; Ohkubo, I.
    Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. [Erratum to document cited in CA146:460121] (2007), FEBS Lett., 581, 3579.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome lysosomes of renal proximal tubular cells Mus musculus 5764
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus role in extracellular matrix remodeling via degradation of fibronectin indicated ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus O89017 14-week-old male C57BL/6J wild-type and legumain-deficient mice analyzed
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Source Tissue

Source Tissue Comment Organism Textmining
kidney protein from kidney tissues used for western blot analysis, unilateral ureteral obstruction in legumain-deficient mice Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay of legumain activity described, fibronectin degradation by legumain shown, enhanced fibronectin processing by overexpression of legumain indicated, experimental design of unilateral ureteral obstruction reveals increased protein accumulation of fibronectin in the renal interstitial area in kidneys from legumain-deficient mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcoumarin-7-amide + H2O effect of legumain on fibronectin degradation analyzed, role of legumain in control of extracellular matrix turnover determined Mus musculus benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
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?
additional information role in extracellular matrix remodeling via degradation of fibronectin indicated Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
AEP
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Mus musculus
asparagine endopeptidase
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Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay of legumain activity at Mus musculus