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Literature summary for 3.4.22.34 extracted from
- Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain (2007), Bioorg. Med. Chem. Lett., 17, 649-653.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibitor specificity profiles of cathepsin B and legumain regarded and used for analysis of the suitability of fluorescent activity-based probes | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | involved in lysosomal processing of bacterial antigens for MHC class II presentation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q99538 | Homo sapiens | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| monocyte | RAW264.7 monocyte lysate utilized for monitoring endogenous legumain by designed activity-based probes, lysates from 816 B cells used for detection assay of endogenous legumain | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
positional scanning combinatorial library of peptide acyloxymethyl ketones (AOMKs) to probe subsite specificity of legumain, design of fluorescent activity-based probes indicating high selectivity and cell-permeability for monitoring legumain activity in complex proteome structures, selectivity of optimized legumain probes in intact cells shown, structure of developed probes indicated | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | involved in lysosomal processing of bacterial antigens for MHC class II presentation | Homo sapiens | ? | - |
? | |
| additional information | subsite specificity of legumain analyzed to design fluorescent activity-based probes for monitoring endogenous legumain activity | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AEP | - |
Homo sapiens |
| Asparaginyl endopeptidase | - |
Homo sapiens |
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