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Literature summary for 3.4.22.34 extracted from

  • Loak, K.; Li, D.N.; Manoury, B.; Billson, J.; Morton, F.; Hewitt, E.; Watts, C.
    Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase (2003), Biol. Chem., 384, 1239-1246.
    View publication on PubMed
Search for more literature for 3.4.22.34

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2-dimethyl-propionic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester weak inhibition Homo sapiens
2,6-dimethyl-benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester enters cells and causes complete, irreversible inhibition of the enzyme, inhibition of autocatalytic processing in vivo Homo sapiens
benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester
-
 Homo sapiens
caspase 1 inhibitor V
-
 Homo sapiens
cystatin C
-
 Homo sapiens
additional information no inhibition by E-64 and leupeptin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Homo sapiens 5768
-
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Homo sapiens enzyme is involved in antigen presentation within class II MHC positive cells and in pro-protein processing peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification autolytic activation upon exposure to acidic pH Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte EBV-infected Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Ala-Ala-Asn-4-methylcouamrin-7-amide + H2O
-
 Homo sapiens benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
 ?
myelin basic protein + H2O
-
 Homo sapiens ?
-
 ?
protein + H2O
-
 Homo sapiens peptides
-
 ?
protein + H2O enzyme is involved in antigen presentation within class II MHC positive cells and in pro-protein processing Homo sapiens peptides
-
 ?
tetanus toxin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AEP
-
 Homo sapiens
asparagine endopeptidase
-
 Homo sapiens
Asparaginyl endopeptidase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens