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Literature summary for 3.4.22.32 extracted from

  • Manosroi, W.; Chankhampan, C.; Manosroi, J.; Manosroi, A.
    In vitro anti-cancer activity comparison of the freeze-dried and spray-dried bromelain from pineapple stems (2017), Chiang Mai J. Sci., 44, 1407-1418 .
No PubMed abstract available
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Application

Application Comment Organism
medicine potential of the stem bromelain to be developed as an active compound for lung cancer therapy because of its high anti-proliferation and apoptosis-induction activity in A549 cells Ananas comosus
pharmacology in vitro anti-cancer activity (anti-proliferation and apoptosis induction) comparison of the freeze-dried and spray-dried bromelain from pineapple stems Ananas comosus

Organism

Organism UniProt Comment Textmining
Ananas comosus P14518 from Thailand
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Purification (Commentary)

Purification (Comment) Organism
bromelain is precipitated from the pineapple stem juice by 95% v/v ethanol and then freeze-dried or spray-dried to get the dry powder Ananas comosus

Source Tissue

Source Tissue Comment Organism Textmining
stem
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 Ananas comosus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Ananas comosus ?
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 ?

General Information

General Information Comment Organism
physiological function the highest anti-proliferation of the freeze-dried and the spray-dried bromelain versus A549 cells are observed with IC50 values of 0.0183 and 0.0264 mg/ml, respectively. For apoptotic induction, the highest activity of the freeze-dried and the spray-dried bromelain is observed on KB (7.53%) and A549 (6.29%) cell lines, respectively. Stem bromelain exhibits apoptotic induction activity on DU145, HT-29, A549, KB, HeLa, and HuTu-80 cells, but not on Hep-G2 cells Ananas comosus