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Literature summary for 3.4.22.32 extracted from

  • Bhui, K.; Prasad, S.; George, J.; Shukla, Y.
    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway (2009), Cancer Lett., 282, 167-176.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ananas comosus phosphorylation and consequent degradation of IkappaBalpha, the inhibitor of the nuclear importing sequences of NF-kappaB, is blocked by bromelain, which also shows anti-inflammatory, anti-invasive and anti-metastatic properties, anti-tumor-initiating effects of bromelain in 2-stage mouse skin tumorigenesis model, overview. Bromelain treatment resulted in upregulation of p53 and Bax and subsequent activation of caspase 3 and caspase 9 with concomitant decrease in Bcl-2, and bromelain inhibits DMBA-induced DNA alkylation damage, overview ?
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Organism

Organism UniProt Comment Textmining
Ananas comosus
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Source Tissue

Source Tissue Comment Organism Textmining
stem
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 Ananas comosus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphorylation and consequent degradation of IkappaBalpha, the inhibitor of the nuclear importing sequences of NF-kappaB, is blocked by bromelain, which also shows anti-inflammatory, anti-invasive and anti-metastatic properties, anti-tumor-initiating effects of bromelain in 2-stage mouse skin tumorigenesis model, overview. Bromelain treatment resulted in upregulation of p53 and Bax and subsequent activation of caspase 3 and caspase 9 with concomitant decrease in Bcl-2, and bromelain inhibits DMBA-induced DNA alkylation damage, overview Ananas comosus ?
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