Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.32 extracted from

  • Hale, L.P.
    Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice (2004), Int. Immunopharmacol., 4, 255-264.
    View publication on PubMed

Application

Application Comment Organism
medicine oral bromelain may potentially modify inflammation within the gastrointestinal tract via local proteolytic activity within the colonic microenvironment Ananas comosus

General Stability

General Stability Organism
the low bromelain activity, particularly in the upper portion of the murine gastrointestinal tract, following oral administration, suggests that extensive gastric inactivation of bromelain may occur in vivo. When formulated in antacid, oral bromelain retains substantial proteolytic activity throughout the gastrointestinal tract (of mice) Ananas comosus

Organism

Organism UniProt Comment Textmining
Ananas comosus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
stem
-
Ananas comosus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Arg-Arg-p-nitroanilide + H2O
-
Ananas comosus benzyloxycarbonyl-Arg-Arg + p-nitroaniline
-
?