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Literature summary for 3.4.22.30 extracted from
- Caricain: A basis for enzyme therapy for coeliac disease (2011), South Afr. J. Sci., 107, 75-79.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| imidazole | - |
Carica papaya |  |
| phenylmethylsulfonyl fluoride | weak inhibition | Carica papaya | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Carica papaya | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gliadin + H2O | a rat liver lysosome assay is used to monitor the extent of detoxification of a gliadin digest by caricain. Pre-incubating the gliadin digest for different durations with caricain allows the kinetics of the detoxification process to be studied. A significant degree of protection (80%) of the lysosomes is achieved with 1.7% w/w of caricain on substrate after incubation for 2 h at 37 °C. The detoxification follows first-order kinetics with a rate constant of 0.00017/sec | Carica papaya | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caricain | - |
Carica papaya |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Carica papaya |
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Release 2023.1 (January 2023)
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