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Literature summary for 3.4.22.29 extracted from

  • Walker, E.; Jensen, L.; Croft, S.; Wei, K.; Fulcher, A.J.; Jans, D.A.; Ghildyal, R.
    Rhinovirus 16 2A protease affects nuclear localization of 3CD during infection (2016), J. Virol., 90, 11032-11042 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.29

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of GFP-tagged or mCherry-tagged enzyme in Escherichia coli rhinovirus A16

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
HRV 3Cpro precursor 3CD + H2O rhinovirus A16 activation of 3C protease, EC 3.4.22.28, of human rhinovirus A-16 3Cpro + 3Dpro
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Organism

Organism UniProt Comment Textmining
rhinovirus A16
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 HRV-A16
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Source Tissue

Source Tissue Comment Organism Textmining
additional information the virus is propagated in Ohio-HeLa cells and COS-7 cells rhinovirus A16
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HRV 3Cpro precursor 3CD + H2O activation of 3C protease, EC 3.4.22.28, of human rhinovirus A-16 rhinovirus A16 3Cpro + 3Dpro
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 ?

Synonyms

Synonyms Comment Organism
2A protease
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 rhinovirus A16
2Apro
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 rhinovirus A16
HRV 2A protease
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 rhinovirus A16
HRV16 2A
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 rhinovirus A16

General Information

General Information Comment Organism
physiological function the human rhinovirus (HRV) 3C (EC 3.4.22.28) and 2A proteases (3Cpro and 2Apro, respectively) are critical in HRV infection, as they are required for viral polyprotein processing as well as proteolysing key host factors to facilitate virus replication. 2Apro activity is required to allow 3Cpro precursor 3CD (HRV 3CD) access to the nucleus. The activity of both 2Apro and 3Cpro is required for 3CD entry into the nucleus. Temporal activities of 2Apro and 3CD/3Cpro activities in HRV serotype16 infection rhinovirus A16