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Literature summary for 3.4.22.29 extracted from

  • Funston, G.M.; Kallioinen, S.E.; de Felipe, P.; Ryan, M.D.; Iggo, R.D.
    Expression of heterologous genes in oncolytic adenoviruses using picornaviral 2A sequences that trigger ribosome skipping (2008), J. Gen. Virol., 89, 389-396.
    View publication on PubMed
Search for more literature for 3.4.22.29

Application

Application Comment Organism
molecular biology picornaviral 2A sequences can be used to express transgenes in oncolytic adenoviruses picornaviridae

Cloned(Commentary)

Cloned (Comment) Organism
to test whether picornaviral 2A sequences can be used to express foreign genes in adenoviruses, 2A skipping site are inserted after the protein IX gene in an oncolytic virus that targets colon cancer cells picornaviridae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information picornaviridae picornaviral 2A sequences are used to express transgenes in oncolytic adenoviruses ?
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 ?
additional information picornaviridae ribosome skipping is a mechanism that allows translation of multiple proteins from a single mRNA, it is based on the use of a picornaviral 2A sequence that causes the ribosome to continue translation after skipping the formation of one peptide bond ?
-
 ?

Organism

Organism UniProt Comment Textmining
picornaviridae
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information picornaviral 2A sequences are used to express transgenes in oncolytic adenoviruses picornaviridae ?
-
 ?
additional information ribosome skipping is a mechanism that allows translation of multiple proteins from a single mRNA, it is based on the use of a picornaviral 2A sequence that causes the ribosome to continue translation after skipping the formation of one peptide bond picornaviridae ?
-
 ?

Synonyms

Synonyms Comment Organism
picornaviral 2A protein
-
 picornaviridae