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Literature summary for 3.4.22.29 extracted from

  • Sousa, C.; Schmid, E.M.; Skern, T.
    Defining residues involved in human rhinovirus 2A proteinase substrate recognition (2006), FEBS Lett., 580, 5713-5717.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
Y289R inactive, substitution of 2Apro A104 can partially restore self-processing on the mutant Y289R Human rhinovirus sp.
Y289R/A104C substitution of 2Apro A104 can partially restore self-processing on the mutant Y289R Human rhinovirus sp.
Y289R/A104S substitution of 2Apro A104 can partially restore self-processing on the mutant Y289R Human rhinovirus sp.

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Val-Ala-Asp (OMe)-fluoromethyl ketone
-
Human rhinovirus sp.
benzyloxycarbonyl-Val-Ala-Met-fluoromethyl ketone
-
Human rhinovirus sp.

Organism

Organism UniProt Comment Textmining
Human rhinovirus sp.
-
serotype 14
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic translation initiation factor 4F p220 subunit + H2O the 2Apro cleavage site on eIF4GI is TLSTR*GPPR Human rhinovirus sp. protein CPa + protein CPb
-
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Synonyms

Synonyms Comment Organism
2A proteinase
-
Human rhinovirus sp.
2Apro
-
Human rhinovirus sp.