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Literature summary for 3.4.22.29 extracted from

  • Toyoda, H.; Nicklin, M.J.H.; Murray, M.G.; Anderson, C.W.; Dunn, J.J.; Studier, F.W.; Wimmer, E.
    A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein (1986), Cell, 45, 761-770.
    View publication on PubMed
Search for more literature for 3.4.22.29

Cloned(Commentary)

Cloned (Comment) Organism
-
 Enterovirus C

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poliovirus polypeptide + H2O Enterovirus C involved in primary processing of poliovirus ?
-
 ?
poliovirus polypeptide + H2O Enterovirus C immediately after polypeptide 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent chain is cleaved intramolecularly ?
-
 ?

Organism

Organism UniProt Comment Textmining
Enterovirus C
-
 type 1 (Mahoney strain)
-
Enterovirus C
-
 type 3
-

Purification (Commentary)

Purification (Comment) Organism
from infected HeLa cells (type S3 cells) Enterovirus C
type 1 Enterovirus C

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell infected Enterovirus C
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3CD-precursor poliovirus protein + H2O
-
 Enterovirus C poliovirus 3C' and 3D'-protein
-
 ?
picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
poliovirus polypeptide + H2O involved in primary processing of poliovirus Enterovirus C ?
-
 ?
poliovirus polypeptide + H2O immediately after polypeptide 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent chain is cleaved intramolecularly Enterovirus C ?
-
 ?