Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibitor synthesis and assay for their biochemical and antiviral activities, structure-activity relationship (SAR) study, ligand docking, overview. The small moieties are primarily tolerated at P1' and the introduction of para-fluoro benzyl at P2 notably improves the inhibitor's potency | Enterovirus A71 | |
N-[(2S)-1-oxo-3-[(3S)-2-oxopiperidin-3-yl]propan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(pentylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(phenylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | docking modeling | Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propylamino)butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(phenylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(benzylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(benzylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(butylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(butylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(cyclohexylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(cyclohexylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(cyclohexylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(dodecylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(hexylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(methylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-(tert-butylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-[(2-methylpropyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-[(4-methylphenyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-[(4-nitrophenyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
N-[(2S)-4-[(furan-2-ylmethyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | - |
Enterovirus A71 | |
Nalpha-(tert-butoxycarbonyl)-N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-4-fluoro-L-phenylalaninamide | - |
Enterovirus A71 | |
Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-4-fluoro-L-phenylalaninamide | - |
Enterovirus A71 | |
rupintrivir | - |
Enterovirus A71 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterovirus A71 | - |
EV71 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | usage of a fluorescence resonance energy transfer (FRET)-based enzyme assay for activity determination | Enterovirus A71 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C protease | - |
Enterovirus A71 |
3Cpro | - |
Enterovirus A71 |
EV71 3Cpro | - |
Enterovirus A71 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00054 | - |
51 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-1-oxo-3-[(3S)-2-oxopiperidin-3-yl]propan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00132 | - |
73 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00134 | - |
57 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00142 | - |
77 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-4-fluoro-L-phenylalaninamide | |
0.00152 | - |
75 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00178 | - |
78 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | Nalpha-(tert-butoxycarbonyl)-N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-4-fluoro-L-phenylalaninamide | |
0.00188 | - |
74 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propylamino)butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.0023 | - |
pH and temperature not specified in the publication | Enterovirus A71 | rupintrivir | |
0.00332 | - |
64 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00371 | - |
76 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(cyclohexylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-4-fluoro-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00381 | - |
50 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00408 | - |
62 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(methylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00486 | - |
59 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(cyclohexylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00507 | - |
65 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-[(2-methylpropyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00622 | - |
63 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(propylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.0063 | - |
72 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-[(furan-2-ylmethyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00783 | - |
61 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(benzylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00821 | - |
58 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(butylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.00875 | - |
52 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.0127 | - |
54 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(cyclohexylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.0176 | - |
53 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(butylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
55 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(phenylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
56 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(benzylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
60 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(phenylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
66 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(tert-butylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
67 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]-4-(pentylamino)butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
68 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(hexylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
69 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-(dodecylamino)-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
70 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-[(4-methylphenyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | |
0.02 | - |
71 mM Tris, pH 7.0, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 10% glycerol, 30°C, substrate (2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR | Enterovirus A71 | N-[(2S)-4-[(4-nitrophenyl)amino]-3,4-dioxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide |