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Literature summary for 3.4.22.28 extracted from

  • Tiew, K.C.; He, G.; Aravapalli, S.; Mandadapu, S.R.; Gunnam, M.R.; Alliston, K.R.; Lushington, G.H.; Kim, Y.; Chang, K.O.; Groutas, W.C.
    Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease (2011), Bioorg. Med. Chem. Lett., 21, 5315-5319.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.28

Inhibitors

Inhibitors Comment Organism Structure
N-[(benzyloxy)carbonyl]glycyl-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-isoleucinamide
-
 Norwalk virus
N-[(benzyloxy)carbonyl]glycyl-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
-
 Norwalk virus
N-[(benzyloxy)carbonyl]glycyl-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-norleucinamide
-
 Norwalk virus
N2-(morpholin-4-ylcarbonyl)-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
-
 Norwalk virus
N2-[(benzyloxy)carbonyl]-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
-
 Norwalk virus

Organism

Organism UniProt Comment Textmining
Norwalk virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
EDANS-EDFHLQGPEDLAK-Dabcyl + H2O
-
 Norwalk virus EDANS-EDFHLQ + GPEDLAK-Dabcyl
-
 ?

Synonyms

Synonyms Comment Organism
3C protease
-
 Norwalk virus
3Cpro
-
 Norwalk virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00087
-
 pH and temperature not specified in the publication Norwalk virus N-[(benzyloxy)carbonyl]glycyl-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-norleucinamide
0.00145
-
 pH and temperature not specified in the publication Norwalk virus N-[(benzyloxy)carbonyl]glycyl-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
0.00182
-
 pH and temperature not specified in the publication Norwalk virus N2-[(benzyloxy)carbonyl]-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
0.0072
-
 pH and temperature not specified in the publication Norwalk virus N2-(morpholin-4-ylcarbonyl)-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
0.0075
-
 pH and temperature not specified in the publication Norwalk virus N-[(benzyloxy)carbonyl]glycyl-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-isoleucinamide