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Literature summary for 3.4.22.28 extracted from

  • Malcolm, B.A.; Lowe, C.; Shechosky, S.; McKay, R.T.; Yang, C.C.; Shah, V.J.; Simon, R.J.; Vederas, J.C.; Santi, D.V.
    Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase (1995), Biochemistry, 34, 8172-8179.
    View publication on PubMed
Search for more literature for 3.4.22.28

Protein Variants

Protein Variants Comment Organism
C24S mutant enzyme in which the nonessential surface cysteine is replaced with serine and which exhibits catalytic parameters identical to those of wild-type enzyme Hepatovirus A

Inhibitors

Inhibitors Comment Organism Structure
(4S)-4-(acetylamino)-N,N-dimethyl-5-oxopentanamide hepatitis A virus Hepatovirus A
acetyl-Ala-Ala-Ala-(N,N'-dimethylglutaminal)
-
 Hepatovirus A
acetyl-Leu-Ala-Ala-(N,N'-dimethylglutaminal)
-
 Hepatovirus A
additional information no inhibition by acetyl-Leu-Ala-Ala-Gln'-thioester enterovirus
additional information no inhibition by acetyl-Leu-Ala-Ala-Gln'-thioester Hepatovirus A

Organism

Organism UniProt Comment Textmining
enterovirus
-
 recombinant enzyme
-
Hepatovirus A
-
 recombinant enzyme
-
Hepatovirus A
-
 wild-type and 3 mutants: C24S
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Arg-Pro-Val-Val-Val-Gln-Gly-Pro-Asn-NH2 + H2O human rhinovirus enterovirus ?
-
 ?
acetyl-Glu-Leu-Arg-Thr-Gln-Ser-Phe-Ser-NH2 + H2O hepatitis A virus Hepatovirus A ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000042
-
 acetyl-Leu-Ala-Ala-(N,N'-dimethylglutaminal) 25°C, mutant enzyme C24S Hepatovirus A