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Literature summary for 3.4.22.28 extracted from

  • Ypma-Wong, M.F.; Semler, B.L.
    In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinase (1987), Nucleic Acids Res., 15, 2069-2088.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Enterovirus C
expressed in HeLa cells Enterovirus C

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
picornavirus polyprotein + H2O Enterovirus C involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O Enterovirus C Mahoney involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
poliovirus polyprotein + H2O Enterovirus C involved in proteolytic processing of poliovirus polyprotein hydrolyzed poliovirus polyprotein
-
?
poliovirus polyprotein + H2O Enterovirus C Mahoney involved in proteolytic processing of poliovirus polyprotein hydrolyzed poliovirus polyprotein
-
?

Organism

Organism UniProt Comment Textmining
Enterovirus C
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type 1, i.e. Mahoney strain
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Enterovirus C Mahoney
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type 1, i.e. Mahoney strain
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Enterovirus C hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Enterovirus C Mahoney hydrolyzed picornavirus polyprotein
-
?
poliovirus P1 precursor polyprotein + H2O trans-cleavage Enterovirus C capsid proteins
-
?
poliovirus P1 precursor polyprotein + H2O trans-cleavage Enterovirus C Mahoney capsid proteins
-
?
poliovirus polyprotein + H2O protease 2A cleavage at COOH-terminal Tyr-Gly bond of P1, i.e. P1/P2 junction, may be necessary before this region of the polyprotein serves as substrate for protease 3C Enterovirus C hydrolyzed poliovirus polyprotein
-
?
poliovirus polyprotein + H2O involved in proteolytic processing of poliovirus polyprotein Enterovirus C hydrolyzed poliovirus polyprotein
-
?
poliovirus polyprotein + H2O protease 2A cleavage at COOH-terminal Tyr-Gly bond of P1, i.e. P1/P2 junction, may be necessary before this region of the polyprotein serves as substrate for protease 3C Enterovirus C Mahoney hydrolyzed poliovirus polyprotein
-
?
poliovirus polyprotein + H2O involved in proteolytic processing of poliovirus polyprotein Enterovirus C Mahoney hydrolyzed poliovirus polyprotein
-
?