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Literature summary for 3.4.22.27 extracted from

  • Clark, A.K.; Yip, P.K.; Grist, J.; Gentry, C.; Staniland, A.A.; Marchand, F.; Dehvari, M.; Wotherspoon, G.; Winter, J.; Ullah, J.; Bevan, S.; Malcangio, M.
    Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain (2007), Proc. Natl. Acad. Sci. USA, 104, 10655-10660.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol 0.5 mM Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
morpholinurea-leucinehomophenylalanine-vinyl phenyl sulfone irreversible CatS inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
microglia
-
 Rattus norvegicus
-
spinal cord
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
 ?
fractalkine + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
CatS
-
 Rattus norvegicus