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Literature summary for 3.4.22.27 extracted from
- Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases (2008), Int. J. Food Sci. Nutr., 60 Suppl 1, 89-98.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | enzyme may be a potential target in rheumatoid arthritis and obesity with its associated cardiovascular risks | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| human recombinant cathepsin S expressed in a murine myeloma NS0 cells is used | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Chlorella powder | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme mediates degradation of the MHC class II invariant chain and participates in antigen processing | ? | - |
? |  |
| additional information | Homo sapiens | protease is implicated in the development of atherosclerotic lesions in both animal | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
| culture condition:antigen-presenting cell | - |
Homo sapiens | - |
| inflammatory cell | - |
Homo sapiens | - |
| lymph node | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme mediates degradation of the MHC class II invariant chain and participates in antigen processing | Homo sapiens | ? | - |
? | |
| additional information | protease is implicated in the development of atherosclerotic lesions in both animal | Homo sapiens | ? | - |
? | |
| Z-Leu-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Leu-Arg + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cathepsin S | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
assay at | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
chlorella powder inhibits peptidase cathepsin S in a dose-concentration manner with 50% inhibitory concentration of 3.46 mg/l | Homo sapiens | Chlorella powder |
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