Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.26 extracted from

  • Gordon, S.G.
    Cancer procoagulant (1994), Methods Enzymol., 244, 568-583.
    View publication on PubMed
Search for more literature for 3.4.22.26

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation with 0.005 mM cysteine and 4 mM KCN Homo sapiens
additional information no activation with 0.005 mM cysteine and 4 mM KCN Rattus norvegicus

General Stability

General Stability Organism
Polyethylene glycol preparation yields stable enzyme Homo sapiens
Polyethylene glycol preparation yields stable enzyme Rattus norvegicus
Prefers lipid environment, phospholipids stabilize Homo sapiens
Prefers lipid environment, phospholipids stabilize Rattus norvegicus
Unstable hydrophobic enzyme which associates with other proteins or itself in tissue extracts and serum Homo sapiens
Unstable hydrophobic enzyme which associates with other proteins or itself in tissue extracts and serum Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alpha1-Aantichymotrypsin weak Homo sapiens
alpha1-Aantichymotrypsin weak Rattus norvegicus
alpha2-Macroglobulin weak Homo sapiens
alpha2-Macroglobulin weak Rattus norvegicus
antipain enhanced in reduced environment Homo sapiens
antipain enhanced in reduced environment Rattus norvegicus
diisopropylfluorophosphate strong Homo sapiens
diisopropylfluorophosphate strong Rattus norvegicus
HgCl2 strong, less effective in reduced environment Homo sapiens
HgCl2 strong, less effective in reduced environment Rattus norvegicus
iodoacetamide strong, still enhanced in reduced environment Homo sapiens
iodoacetamide strong, still enhanced in reduced environment Rattus norvegicus
leupeptin enhanced in reduced environment Homo sapiens
leupeptin enhanced in reduced environment Rattus norvegicus
additional information cystatin, alpha1-antiprotease, antithrombin III Homo sapiens
additional information cystatin, alpha1-antiprotease, antithrombin III Rattus norvegicus
Peptidyl chloromethanes
-
 Homo sapiens
Peptidyl chloromethanes
-
 Rattus norvegicus
Peptidyl diazomethanes
-
 Homo sapiens
Peptidyl diazomethanes
-
 Rattus norvegicus
Peptidyl dimethylsulfonium salts
-
 Homo sapiens
Peptidyl dimethylsulfonium salts
-
 Rattus norvegicus
phenylmethylsulfonyl fluoride
-
 Homo sapiens
phenylmethylsulfonyl fluoride
-
 Rattus norvegicus
trans-epoxysuccinyl-L-leucyl-amido(4-guanidino)butane enhanced in reduced environment Homo sapiens
trans-epoxysuccinyl-L-leucyl-amido(4-guanidino)butane enhanced in reduced environment Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement, 7 mM Homo sapiens
Ca2+ requirement, 7 mM Rattus norvegicus
Mg2+ 10 mM Homo sapiens
Mg2+ 10 mM Rattus norvegicus
Mg2+ requirement, can replace Ca2+ Homo sapiens
Mg2+ requirement, can replace Ca2+ Rattus norvegicus
Mn2+ requirement, can replace Ca2+ Homo sapiens
Mn2+ requirement, can replace Ca2+ Rattus norvegicus
Mn2+ but different binding site than Ca2+ (or Mg2+), 0.02 mM Homo sapiens
Mn2+ but different binding site than Ca2+ (or Mg2+), 0.02 mM Rattus norvegicus
additional information binding cancer procoagulant to a surface changes its divalent ion requirements Homo sapiens
additional information binding cancer procoagulant to a surface changes its divalent ion requirements Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
 Rattus norvegicus
additional information
-
 amino acid composition of rabbit V2 and human amnion-chorion enzymes Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Oxidation Stability

Oxidation Stability Organism
sensitive to oxidation of active site, 1 mM 2-mercaptoethanol and 5 mM KCN or 0.005 mM cysteine and 4 mM KCN stabilize Homo sapiens
sensitive to oxidation of active site, 1 mM 2-mercaptoethanol and 5 mM KCN or 0.005 mM cysteine and 4 mM KCN stabilize Rattus norvegicus

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein no glycoprotein Homo sapiens
no glycoprotein no glycoprotein Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
amelanotic melanoma cell
-
 Rattus norvegicus
-
carcinoma cell
-
 Rattus norvegicus
-
Lewis lung carcinoma cell
-
 Rattus norvegicus
-
additional information unique in tumor Homo sapiens
-
additional information unique in tumor Rattus norvegicus
-
additional information unique in fetal tissues, not in normally differentiated tissues Homo sapiens
-
additional information unique in fetal tissues, not in normally differentiated tissues Rattus norvegicus
-
placenta amnion-chorion tissue Homo sapiens
-
Walker carcinoma 256 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O primary cleavage site: Tyr21-Asp22, secondary sites: Asp14-Ser15 and Thr18-Glu19 Homo sapiens Factor Xa + ?
-
 ?
Factor X + H2O primary cleavage site: Tyr21-Asp22, secondary sites: Asp14-Ser15 and Thr18-Glu19 Rattus norvegicus Factor Xa + ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus