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Literature summary for 3.4.22.26 extracted from
- Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue (1985), Biochemistry, 24, 5558-5567.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HgCl2 | 0.1 mM | Oryctolagus cuniculus |  |
| iodoacetamide | 1 mM | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid composition compared with that of other factor X-activators and cathepsin B | Oryctolagus cuniculus |
| 68000 | - |
1 * 68000, rabbit, SDS-PAGE, reducing or non-reducing conditions | Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | Oryctolagus cuniculus | factor X-activating cysteine proteinase | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| no glycoprotein | no glycoprotein | Oryctolagus cuniculus |
| no glycoprotein | no glucosamine or galactosamine and less than 1 mol hexose or sialic acid/mol protein | Oryctolagus cuniculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| two different procedures | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amelanotic melanoma cell | - |
Oryctolagus cuniculus | - |
| carcinoma cell | V2 carcinoma (rabbit) | Oryctolagus cuniculus | - |
| Lewis lung carcinoma cell | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | - |
Oryctolagus cuniculus | Factor Xa + ? | - |
? | |
| factor X + H2O | factor X-activating cysteine proteinase | Oryctolagus cuniculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 68000, rabbit, SDS-PAGE, reducing or non-reducing conditions | Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 4.8 | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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