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Literature summary for 3.4.22.2 extracted from
- Carboxy terminal extended phytocystatins are bifunctional inhibitors of papain and legumain cysteine proteinases (2007), FEBS Lett., 581, 2914-2918.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| barley cystatin protease inhibitor | inhibited by various cystatin vatiants, HvCPI-1, HvCPI-2, HvCPI-3, HvCPI-4, HvCPI-5, HvCPI-6 | Carica papaya | |
| additional information | not inhibited by barley cystatin protease inhibitor-4 (Q86P), barley cystatin protease inhibitor-4 (N-term-DELTAA142 (Q86P)), barley cystatin protease inhibitor-4 (N-term-DELTAL150 (Q86P)), barley cystatin protease inhibitor-4 (DELTAT143-C-term), barley cystatin protease inhibitor-4 (DELTAT143-C-term (N177K)), barley cystatin protease inhibitor-4 (DELTAG151-C-term), and barley cystatin protease inhibitor-4 (DELTAG151-C-term (N177K)) | Carica papaya |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Carica papaya | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-benzoyl-DL-arginine-2-naphthylamide + H2O | - |
Carica papaya | N-benzoyl-DL-arginine + 2-naphthylamine | - |
? |  |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition constants for various barley cystatin protease inhibitor variants | Carica papaya |
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