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Literature summary for 3.4.22.15 extracted from

  • Shenoy, R.T.; Sivaraman, J.
    Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors (2011), J. Struct. Biol., 173, 14-19.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor Phe-Tyr-(OBut)-COCHO, hanging drop vapor diffusion method, using 15% (w/v) PEG 8K and 200 mM ammonium sulfate, pH 4.8. In complex with inhibitor Phe-Tyr-(tert-Bu)-diazomethylketone, hanging drop vapor diffusion method, using 30% (w/v) PEG 8K and 200 mM ammonium sulfate, pH 5.2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Phe-Tyr-(OBut)-COCHO potent, reversible, synthetic peptidyl inhibitor of cathepsin L Homo sapiens
Phe-Tyr-(tert-Bu)-diazomethylketone irreversible inhibitor that can inactivate cathepsin L at micromolar concentrations Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07711
-
-

Synonyms

Synonyms Comment Organism
CatL
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000006
-
Phe-Tyr-(OBut)-COCHO pH and temperature not specified in the publication Homo sapiens