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Literature summary for 3.4.22.15 extracted from

  • Wartmann, T.; Mayerle, J.; Kaehne, T.; Sahin-Toth, M.; Ruthenbuerger, M.; Matthias, R.; Kruse, A.; Reinheckel, T.; Peters, C.; Weiss, F.U.; Sendler, M.; Lippert, H.; Schulz, H.U.; Aghdassi, A.; Dummer, A.; Teller, S.; Halangk, W.; Lerch, M.M.
    Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice (2010), Gastroenterology, 138, 726-737.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-
vesicle secretory vesicle Homo sapiens 31982
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trypsinogen + H2O Homo sapiens cathepsin L inactivates human trypsinogen, CTSL-induced cleavage of trypsinogen occurs 3 amino acids toward the C-terminus from the cathepsin B activation site and results in a truncated, inactive form of trypsin and an elongated propeptide (trypsinogen activation peptide) trypsin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
?
trypsinogen + H2O cathepsin L inactivates human trypsinogen, CTSL-induced cleavage of trypsinogen occurs 3 amino acids toward the C-terminus from the cathepsin B activation site and results in a truncated, inactive form of trypsin and an elongated propeptide (trypsinogen activation peptide) Homo sapiens trypsin + ?
-
?

Synonyms

Synonyms Comment Organism
CTSL
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4.2 4.8 the rate of trypsin inactivation is strongly pH dependent in the range between 4.2 and 4.8 in the presence of Ca2+ Homo sapiens
5.2 5.8 the rate of trypsin inactivation is strongly pH dependent in the range between 5.2 and 5.8 in the absence of Ca2+ Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
3.6 6.2 activity of cathepsin L increases from pH 3.6 to 6.2 and is independent of the calcium concentration, The rate of trypsin inactivation by cathepsin L is thus approximately 10 times faster at pH 4.0 than at pH 5.5 Homo sapiens

General Information

General Information Comment Organism
malfunction severity of pancreatitis is reduced in cathepsin L-deficient mice, whereas apoptosis and intrapancreatic trypsin activity are increased Homo sapiens
physiological function cathepsin L inactivates trypsinogen and counteracts the ability of cathepsin B to form active trypsin Homo sapiens