Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
vesicle | secretory vesicle | Homo sapiens | 31982 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypsinogen + H2O | Homo sapiens | cathepsin L inactivates human trypsinogen, CTSL-induced cleavage of trypsinogen occurs 3 amino acids toward the C-terminus from the cathepsin B activation site and results in a truncated, inactive form of trypsin and an elongated propeptide (trypsinogen activation peptide) | trypsin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
trypsinogen + H2O | cathepsin L inactivates human trypsinogen, CTSL-induced cleavage of trypsinogen occurs 3 amino acids toward the C-terminus from the cathepsin B activation site and results in a truncated, inactive form of trypsin and an elongated propeptide (trypsinogen activation peptide) | Homo sapiens | trypsin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTSL | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.2 | 4.8 | the rate of trypsin inactivation is strongly pH dependent in the range between 4.2 and 4.8 in the presence of Ca2+ | Homo sapiens |
5.2 | 5.8 | the rate of trypsin inactivation is strongly pH dependent in the range between 5.2 and 5.8 in the absence of Ca2+ | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
3.6 | 6.2 | activity of cathepsin L increases from pH 3.6 to 6.2 and is independent of the calcium concentration, The rate of trypsin inactivation by cathepsin L is thus approximately 10 times faster at pH 4.0 than at pH 5.5 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | severity of pancreatitis is reduced in cathepsin L-deficient mice, whereas apoptosis and intrapancreatic trypsin activity are increased | Homo sapiens |
physiological function | cathepsin L inactivates trypsinogen and counteracts the ability of cathepsin B to form active trypsin | Homo sapiens |