Application | Comment | Organism |
---|---|---|
medicine | cathepsin L is a target in the treatment of patients with metastatic bone disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | the pro-enzyme is normally activated in the acidic environment of lysosomes | Homo sapiens | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
1 * 21000 + 1 * 5000, active form | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
E-cadherin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoclast | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
E-cadherin + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 21000 + 1 * 5000, active form | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | upregulation of osteoclast cathepsin L activity and secretion occurs by cytokines promoting bone resorption, c-Src tyrosine kinase, interleukin-1alpha, interleukin-6, and tumor necrosis factor-alpha. Intracellular expression levels of cathepsin L are upregulated in many human tumors. In U-87MG glioblastoma cells, vascular endothelial growth factor upregulates at transcriptional level cathepsin L | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cathepsin L is involved in bone remodeling processes and contributes to facilitate bone metastasis formation | Homo sapiens |