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Literature summary for 3.4.22.15 extracted from

  • Shimada, N.; Ohno-Matsui, K.; Iseki, S.; Koike, M.; Uchiyama, Y.; Wang, J.; Yoshida, T.; Sato, T.; Peters, C.; Mochizuki, M.; Morita, I.
    Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization (2010), Am. J. Pathol., 176, 2571-2580.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-FF-fluoromethylketone cathepsin L-specific inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial progenitor cell VE cadherin-positive endothelial progenitor cells but not CD43-positive or Iba-1-positive cells, are the major cells contributing to the production of cathepsin L Mus musculus
-

Synonyms

Synonyms Comment Organism
CatL
-
Mus musculus

General Information

General Information Comment Organism
malfunction inhibition of cathepsin L by specific inhibitors results in a significant decrease of intraocular neovascularization, a similar decrease of neovascularization is found in cathepsin L-deficient mice Mus musculus
physiological function cathepsin L plays a critical role in intraocular angiogenesis Mus musculus