Literature summary for 3.4.22.15 extracted from

Ito, H.; Watanabe, M.; Kim, Y.T.; Takahashi, K.
Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues (2009), J. Enzyme Inhib. Med. Chem., 24, 279-286.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-furancarbonyl-leucyl-leucyl-leucinal	-	Rattus norvegicus
acetyl-prolyl-leucyl-leucyl-leucinal	-	Rattus norvegicus
acetyl-prolyl-prolyl-leucyl-leucyl-leucinal	-	Rattus norvegicus
benzyloxycarbonyl-leucyl-leucyl-leucinal	-	Rattus norvegicus
isonicotinyl-leucyl-leucyl-leucinal	-	Rattus norvegicus
morpholinylsuccinyl-leucyl-leucyl-leucinal	-	Rattus norvegicus
nicotinyl-leucyl-leucyl-leucinal	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Rattus norvegicus	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000019	-	pH 5.0, 37°C	Rattus norvegicus	acetyl-prolyl-prolyl-leucyl-leucyl-leucinal
0.00002	-	pH 5.0, 37°C	Rattus norvegicus	isonicotinyl-leucyl-leucyl-leucinal
0.000027	-	pH 5.0, 37°C	Rattus norvegicus	nicotinyl-leucyl-leucyl-leucinal
0.000044	-	pH 5.0, 37°C	Rattus norvegicus	2-furancarbonyl-leucyl-leucyl-leucinal
0.000048	-	pH 5.0, 37°C	Rattus norvegicus	morpholinylsuccinyl-leucyl-leucyl-leucinal
0.000057	-	pH 5.0, 37°C	Rattus norvegicus	acetyl-prolyl-leucyl-leucyl-leucinal
0.000163	-	pH 5.0, 37°C	Rattus norvegicus	benzyloxycarbonyl-leucyl-leucyl-leucinal

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Release 2023.1 (January 2023)