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Literature summary for 3.4.22.15 extracted from

  • Marks, N.; Berg, M.J.
    Rat brain cathepsin L: characterization and differentiation from cathepsin B utilizing opioid peptides (1987), Arch. Biochem. Biophys., 259, 131-143.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Phe-Ala-CNH2
-
 Rattus norvegicus
Benzyloxycarbonyl-Phe-Phe-CHN2
-
 Rattus norvegicus
diazomethanes irreversible inhibition of hydrolysis of leucine enkephalin Rattus norvegicus
leupeptin reversible inhibition of hydrolysis of leucine enkephalin Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00125
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
 Rattus norvegicus
0.0208
-
 Leu-Trp-Met-Arg-Phe-Ala
-
 Rattus norvegicus
0.0825
-
 leucine enkephalin
-
 Rattus norvegicus
0.1096
-
 methionine enkephalin-Arg-Phe
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34900
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
 Rattus norvegicus ?
-
 ?
Leu-Trp-Met-Arg-Phe-Ala + H2O
-
 Rattus norvegicus Leu-Trp-Met + Arg-Phe-Ala
-
 ?
methionine enkephalin-Arg-Phe + H2O
-
 Rattus norvegicus ?
-
 ?
Tyr-Gly-Gly-Phe-Leu + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Leu
-
 ?
Tyr-Gly-Gly-Phe-Leu-Arg + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Leu-Arg
-
 ?
Tyr-Gly-Gly-Phe-Leu-Arg-Arg + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Leu-Arg-Arg
-
 ?
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Leu-Arg-Arg-Ile
-
 ?
Tyr-Gly-Gly-Phe-Met + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Met
-
 ?
Tyr-Gly-Gly-Phe-Met-Arg-Arg + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Met-Arg-Arg
-
 ?
Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu + H2O cleavage sites Gly-Gly and Met-Arg Rattus norvegicus ?
-
 ?
Tyr-Gly-Gly-Phe-Met-Arg-Phe + H2O cleavage sites: Gly-Gly and Met-Arg Rattus norvegicus ?
-
 ?
Tyr-Gly-Gly-Phe-Met-Arg-Phe-NH2 + H2O cleavage sites Gly-Gly and Met-Arg Rattus norvegicus ?
-
 ?
Tyr-Gly-Gly-Phe-Met-NH2 + H2O
-
 Rattus norvegicus Tyr-Gly + Gly-Phe-Met-NH2
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.53
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
 Rattus norvegicus
26.6
-
 Leu-Trp-Met-Arg-Phe-Ala
-
 Rattus norvegicus
33.9
-
 leucine enkephalin
-
 Rattus norvegicus
43.2
-
 methionine enkephalin-Arg-Phe
-
 Rattus norvegicus