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Literature summary for 3.4.22.10 extracted from

  • Berge, A.; Björck, L.
    Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins (1995), J. Biol. Chem., 270, 9862-9867.
    View publication on PubMed
Search for more literature for 3.4.22.10

Inhibitors

Inhibitors Comment Organism Structure
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
 Streptococcus pyogenes

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Streptococcus pyogenes
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pyogenes by removal of M1 protein and protein H from the streptococcal surface the enzyme regulates the bacterial cell-cell interactions, and perhaps also interactions with epithelial cells. Through expression of streptopain the enzyme can modify the composition of the surface proteins in response to environmental conditions. Such a mechanism will facilitate the adaption of the bacterium to its host ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification complete removal of the 118 amino acids from the SCP zymogen results in formation of SCP Streptococcus pyogenes

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus pyogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ile-Pro-Arg-p-nitroanilide + H2O
-
 Streptococcus pyogenes ?
-
 ?
additional information an unprotonated imidazole ring and the protonated form of the single sulfhydryl group are essential for activity Streptococcus pyogenes ?
-
 ?
additional information the enzyme also at low concentrations efficiently removes M1 protein and protein H from the streptococcal surface Streptococcus pyogenes ?
-
 ?
additional information by removal of M1 protein and protein H from the streptococcal surface the enzyme regulates the bacterial cell-cell interactions, and perhaps also interactions with epithelial cells. Through expression of streptopain the enzyme can modify the composition of the surface proteins in response to environmental conditions. Such a mechanism will facilitate the adaption of the bacterium to its host Streptococcus pyogenes ?
-
 ?