Inhibitors | Comment | Organism | Structure |
---|---|---|---|
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | i.e. E64, inhibits the capillary permeability increasing effect of the enzyme | Streptococcus pyogenes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Streptococcus pyogenes | the enzyme is a virulence factor of Streptococcus pyogenes inducing the release of histamine in mast cells, basophils, and mononuclear cells, and increasing capillary permeability and histamine release in skin of guinea pigs, the recombinant enzyme shows mitogenic activity with human T-cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is a virulence factor of Streptococcus pyogenes inducing the release of histamine in mast cells, basophils, and mononuclear cells, and increasing capillary permeability and histamine release in skin of guinea pigs, the recombinant enzyme shows mitogenic activity with human T-cells | Streptococcus pyogenes | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SPE B/SCP | - |
Streptococcus pyogenes |
streptococcal pyrogenic exotoxin B/cysteine protease | - |
Streptococcus pyogenes |