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Literature summary for 3.4.22.10 extracted from

  • von Pawel-Rammingen, U.; Johansson, B.P.; Bjorck, L.
    IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G (2002), EMBO J., 21, 1607-1615.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.10

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pyogenes thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system ?
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Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification SpeB is secreted as a 40000 Da proenzyme that is converted into a mature 28000 Da active proteinase by autocatalytic cleavage Streptococcus pyogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IgA + H2O degradation of the carboxy-terminal part of the heavy chain Streptococcus pyogenes ?
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IgD + H2O degradation of the carboxy-terminal part of the heavy chain Streptococcus pyogenes ?
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IgE + H2O degradation of the carboxy-terminal part of the heavy chain Streptococcus pyogenes ?
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IgG + H2O the enzyme cleaves IgG in the flexible hinge region of the IgG heavy chain, generating two Fab fragments and Fc fragment. SpeB cleaves the heavy chain at a defined site between glycine residues 236 and 237 Streptococcus pyogenes Fab fragment + Gc fragments
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IgM + H2O degradation of the carboxy-terminal part of the heavy chain Streptococcus pyogenes ?
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 ?
additional information thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system Streptococcus pyogenes ?
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 ?

Synonyms

Synonyms Comment Organism
SpeB
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 Streptococcus pyogenes