Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-L-isoleucyl-L-proline methyl ester | activity of caspase 3 is significantly reduced in Dengue virus-infected HepG2 cells treated with cathepsin B or S inhibitor. Treatment with cathepsin B inhibitor also reduces the activity of caspase 9 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07858 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced cathepsin B expression using RNA interference mimicks pharmacological inhibition of the enzyme and confirms the contribution of cathepsin B to apoptotic events induced by Dengue virus in HepG2 cells | Homo sapiens |
physiological function | cathepsin B activates both caspase-9 and caspase-3 | Homo sapiens |