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Literature summary for 3.4.22.1 extracted from

  • Morchang, A.; Panaampon, J.; Suttitheptumrong, A.; Yasamut, U.; Noisakran, S.; Yenchitsomanus, P.T.; Limjindaporn, T.
    Role of cathepsin B in dengue virus-mediated apoptosis (2013), Biochem. Biophys. Res. Commun., 438, 20-25.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-L-isoleucyl-L-proline methyl ester activity of caspase 3 is significantly reduced in Dengue virus-infected HepG2 cells treated with cathepsin B or S inhibitor. Treatment with cathepsin B inhibitor also reduces the activity of caspase 9 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
cathepsin B
-
Homo sapiens

General Information

General Information Comment Organism
malfunction reduced cathepsin B expression using RNA interference mimicks pharmacological inhibition of the enzyme and confirms the contribution of cathepsin B to apoptotic events induced by Dengue virus in HepG2 cells Homo sapiens
physiological function cathepsin B activates both caspase-9 and caspase-3 Homo sapiens