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Literature summary for 3.4.22.1 extracted from

  • Johnson, E.M.; Doyle, J.D.; Wetzel, J.D.; McClung, R.P.; Katunuma, N.; Chappell, J.D.; Washington, M.K.; Dermody, T.S.
    Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis (2009), J. Virol., 83, 9630-9640.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Application

Application Comment Organism
medicine pharmacologic modulation of cathepsin activity diminishes reovirus disease severity Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information survival rate of Ctsb-/- mice infected with reovirus is enhanced in comparison to that of wild-type mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J mice
-
Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
intestine
-
 Mus musculus
-
L-929 cell
-
 Mus musculus
-
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
CTSB
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the cathepsin family of endosomal proteases is required for proteolytic processing of several viruses during entry into host cells, cathepsins contribute to reovirus tropism, spread, and disease outcome. Mammalian reoviruses utilize cathepsins B, L, and S for disassembly of the virus outer capsid and activation of the membrane penetration machinery. The survival rate of Ctsb-/- mice infected with reovirus is enhanced in comparison to that of wild-type mice, viremia in wild-type and cathepsin-deficient mice following peroral inoculation, overview Mus musculus