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Literature summary for 3.4.22.1 extracted from

  • Eykelbosh, A.J.; Van Der Kraak, G.
    A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis (2010), Comp. Biochem. Physiol. A, 156, 218-223.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information serum-starvation increases cathepsin B-like activation in zebrafish follicles, not due to an increase in gene expression. No effects on cathepsin B activity by human chorionic gonadotropin and 17beta-estradiol Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me
-
Danio rerio
additional information No effects on cathepsin B activity by human chorionic gonadotropin and 17beta-estradiol Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Danio rerio 5764
-

Organism

Organism UniProt Comment Textmining
Danio rerio Q6PH75
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vitelline gland
-
Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin + H2O
-
Danio rerio N-benzyloxycarbonyl-Arg-Arg + 4-methyl-7-aminocoumarin
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
assay at Danio rerio

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Danio rerio

General Information

General Information Comment Organism
physiological function cathepsin B is involved in the regulation of apoptosis during serum-starvation in teleost follicles. Cathepsin B may play a role in the activation of the executioner caspase-3 Danio rerio