Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 Me | a specific cathepsin B inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
D-283MED cell | a medulloblastoma cell line | Homo sapiens | - |
DAOY cell | a medulloblastoma cell line | Homo sapiens | - |
neuroectodermal tumor cell | - |
Homo sapiens | - |
primitive neuroectodermal tumor cell | - |
Homo sapiens | - |
SH-SY5Y cell | a neuroblastoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-Arg-Arg-4-methyl-7-amidocoumarin + H2O | - |
Homo sapiens | Ac-Arg-Arg + 4-methyl-7-aminocoumarin | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | SPARC, i.e. secreted protein, acidic and rich in cysteine, a matrix-associated glycoprotein, expression induces autophagy, which results in the elevation of cathepsin B and subsequent mitochondria-mediated apoptosis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | specific blocking cathepsin B expression suppresses apoptosis but does not affect autophagy, which suggests that cathepsin B is a molecular link between autophagy and apoptosis. Cathepsin B inhibition decreases the SPARC-induced release of cytochrome c | Homo sapiens |
physiological function | cathepsin B is a molecular link between autophagy and apoptosis. Cathepsin B mediates SPARC-induced apoptosis in primitive neuroectodermal tumor, PNET, cells, overview. SPARC is secreted protein, acidic and rich in cysteine, a matrix-associated glycoprotein. Cathepsin B inhibition decreases the SPARC-induced release of cytochorome c indicating that the release is due to cathepsin B activity | Homo sapiens |