Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of CatB by siRNA leads to 33% residual activity of CatB, but has no effect on caspase 3/7 activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arsenite | i.e. arsenic trioxide, inhibits CatB in glioblastoma cells, 20% inhibition at 0.022 mM, 50% at 0.020 mM | Homo sapiens | |
CA-074-Me | strong inhibition | Homo sapiens | |
CLIK148 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | upregulation of CatB | Homo sapiens | - |
U-87MG cell | upregulation of CatB | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CatB | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | arsenite treatment of human glioblastoma cells induces autophagosome formation and permeabilization of mitochondria, followed by caspase 3/7-mediated apoptosis. Arsenite toxicity involves a complex interplay between autophagy and apoptosis in human glioblastoma cells and is associated with inhibition of CatB, mechanism, overview | Homo sapiens |