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Literature summary for 3.4.22.1 extracted from

  • Aoki, T.; Kataoka, H.; Ishibashi, R.; Nozaki, K.; Hashimoto, N.
    Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms (2008), Stroke, 39, 2603-2610.
    View publication on PubMed
Search for more literature for 3.4.22.1

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis by quantitative RT-PCR, expression patterns of cathepsin B and endogenous inhibitor cystatin C Homo sapiens
expression analysis by quantitative RT-PCR, expression patterns of cathepsin B and endogenous inhibitor cystatin C Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cystatin C an endogenous inhibitor of cysteine cathepsins, expression patterns of cathepsin B and cystatin C Homo sapiens
cystatin C an endogenous inhibitor of cysteine cathepsins, expression patterns of cathepsin B and cystatin C Rattus norvegicus
NC-2300 i.e. monosodium (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylate, a cysteine cathepsin inhibitor Homo sapiens
NC-2300 i.e. monosodium (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylate, a cysteine cathepsin inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin B is expressed in cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview ?
-
 ?
additional information Rattus norvegicus cathepsin B is expressed in induced cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
artery cerebral arterial walls Homo sapiens
-
artery cerebral arterial walls Rattus norvegicus
-
brain cathepsin B is expressed in cerebral aneurysms and aneurysmal walls, and promotes the progression of cerebral aneurysms Homo sapiens
-
brain cathepsin B is expressed in induced cerebral aneurysms and aneurysmal walls, and promotes the progression of cerebral aneurysms Rattus norvegicus
-
additional information immunohistochemic expression analysis in cerebral arterial walls and aneurysms, overview Homo sapiens
-
additional information immunohistochemic expression analysis in cerebral arterial walls and aneurysms, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
additional information cathepsin B is expressed in cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview Homo sapiens ?
-
 ?
additional information cathepsin B is expressed in induced cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Homo sapiens
6
-
 assay at Rattus norvegicus