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Literature summary for 3.4.22.1 extracted from

  • Vasiljeva, O.; Korovin, M.; Gajda, M.; Brodoefel, H.; Bojic, L.; Krueger, A.; Schurigt, U.; Sevenich, L.; Turk, B.; Peters, C.; Reinheckel, T.
    Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice (2008), Oncogene, 27, 4191-4199.
    View publication on PubMed
Search for more literature for 3.4.22.1

Protein Variants

Protein Variants Comment Organism
additional information high-grade mammary carcinomas in cathepsin B-deficient mice show reduced tumour cell proliferation and delayed development, tumour necrosis factor-alpha can reverse the effect, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus absence of Ctsb significantly impairs development of high-grade invasive ductal carcinomas and reduces the metastatic burden in the lungs, and cancer cells lacking Ctsb exhibit significantly higher resistance to apoptosis induction by the lysosomotropic agent Leu-Leu-OMe ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information absence of Ctsb significantly impairs development of high-grade invasive ductal carcinomas and reduces the metastatic burden in the lungs, and cancer cells lacking Ctsb exhibit significantly higher resistance to apoptosis induction by the lysosomotropic agent Leu-Leu-OMe Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
CTSB
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 Mus musculus