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Literature summary for 3.4.22.1 extracted from

  • Sakamoto, M.; Miyamoto, K.; Wu, Z.; Nakanishi, H.
    Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat (2008), Neurosci. Lett., 442, 292-296.
    View publication on PubMed
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
CA074 an irreversible CB inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is released by activated microglia accumulating in the granule cell layer of the lingual and central lobe Rattus norvegicus
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lysosome
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 Rattus norvegicus 5764
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Metals/Ions

Metals/Ions Comment Organism Structure
monomethylmercuric cation treatment leads to increased cathepsin B mainly in activated microglia which accumulate in the granule cell layer of the cerebellum Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus cathepsin B secreted by activated microglia is closely associated with the MeHg-induced severe pyknotic changes of the cerebellar granule cells, overview. Cathepsin B is involved in apoptotic processes ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Rattus norvegicus
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cerebellum
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 Rattus norvegicus
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microglia from the granule cell layer of the lingual and central lobe Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin B secreted by activated microglia is closely associated with the MeHg-induced severe pyknotic changes of the cerebellar granule cells, overview. Cathepsin B is involved in apoptotic processes Rattus norvegicus ?
-
 ?