Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | 3.5fold higher up-regulation of cathepsin B transcript in resistant than in the susceptible snail after Schistosoma mansoni parasite exposure | Biomphalaria glabrata |
Cloned (Comment) | Organism |
---|---|
cloning from a hepatopancreas cDNA library of wild-type strain, adult and Schistosoma mansoni-resistant, BS-90 snails, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time RT-PCR | Biomphalaria glabrata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
E-64 | - |
Biomphalaria glabrata |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Biomphalaria glabrata | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Biomphalaria glabrata | differential regulation of snail cathepsin B transcript pre- and postparasite exposure, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Biomphalaria glabrata | A7LM75 | Schistosoma mansoni-resistant BS-90, or Salvador strain, and Schistosoma mansoni-susceptible M-line strains | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Biomphalaria glabrata |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides | non-active site residue Gln109 and active site Cys115 play an important role in the catalytic mechanism | Biomphalaria glabrata |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
headfoot | anterior region | Biomphalaria glabrata | - |
hepatopancreas | posterior region, main activity | Biomphalaria glabrata | - |
ovotestis | posterior region | Biomphalaria glabrata | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
resistant snail BS-90 extract: about 21466 fluorescence units released/min/microgram protein compared with the about 6066 fluorescence units released/min/microgram protein for the susceptible M-line snail extract, overview | Biomphalaria glabrata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O | a fluorogenic substrate | Biomphalaria glabrata | carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | differential regulation of snail cathepsin B transcript pre- and postparasite exposure, overview | Biomphalaria glabrata | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTSB | - |
Biomphalaria glabrata |
More | cathepsin B of Biomphalaria glabrata belongs to the C1A family of peptidases | Biomphalaria glabrata |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Biomphalaria glabrata |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 6.8 | assay at | Biomphalaria glabrata |