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Literature summary for 3.4.22.1 extracted from

  • Hwang, J.H.; Lee, S.H.; Lee, K.H.; Lee, K.Y.; Kim, H.; Ryu, J.K.; Yoon, Y.B.; Kim, Y.T.
    Cathepsin B is a target of Hedgehog signaling in pancreatic cancer (2009), Cancer Lett., 273, 266-272.
    View publication on PubMed
Search for more literature for 3.4.22.1

Application

Application Comment Organism
diagnostics CATB is a potent and independent prognostic marker for resectable pancreatic adenocarcinoma Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative expression analysis of CATB Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-(L-3-trans-propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester i.e. CA074Me, inhibits the enzyme and PANC-1 cellular invasiveness, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07858 gene CATB or CTSB
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Source Tissue

Source Tissue Comment Organism Textmining
PANC-1 cell expresses Sonic Hedgehog Homo sapiens
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pancreatic cancer cell from pancreatic ductal adenocarcinoma tissue Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
CatB
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 Homo sapiens