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Literature summary for 3.4.22.1 extracted from

  • Rhee, S.H.; Kang, J.; Nahm, D.S.
    Cystatins and cathepsin B during orthodontic tooth movement (2009), Am. J. Orthod. Dentofacial. Orthop., 135, 99-105.
    View publication on PubMed
Search for more literature for 3.4.22.1

Application

Application Comment Organism
diagnostics cathepsin B is a biologic marker reflecting the clinical state of inflammatory disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cystatin
-
 Homo sapiens
iodoacetic acid
-
 Homo sapiens
additional information ruthenium(II)-arene compounds behave as powerful inhibitors Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens cathepsin B is an intracellular lysosomal cysteine proteinase that can degrade extracellular components including collagen and protein turnover in the lysosomal system. Cathepsin B plays an important role in the resolution of organic matrix, a final step in bone resorption. It is also known to play an important role in the initiation and perpetuation of inflammatory processes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gingival fluid from distal sulcus, in periodontitis Homo sapiens
-
tooth enzyme before and after canine extraction, force application reduces the enzyme activity in gingival crevicular fluid to 41.5% of maximal activity Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity in gingival crevicular fluid of left and right sides, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
 Homo sapiens ?
-
 ?
additional information cathepsin B is an intracellular lysosomal cysteine proteinase that can degrade extracellular components including collagen and protein turnover in the lysosomal system. Cathepsin B plays an important role in the resolution of organic matrix, a final step in bone resorption. It is also known to play an important role in the initiation and perpetuation of inflammatory processes Homo sapiens ?
-
 ?
Nalpha-benzoyl-Val-Lys-Lys-Arg-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Homo sapiens