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Literature summary for 3.4.22.1 extracted from
- S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B (2002), Biochem. J., 361, 613-619.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D22A | sensitive to autocatalytic degradation at both 0°C and 25°C | Homo sapiens |
| D22A/H110A | dramatic loss of exopeptidase activity | Homo sapiens |
| H110A | slight loss of activity at 0°C, half-life at 25°C about 9 h | Homo sapiens |
| H111A | decrease in exopeptidase activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P07858 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme prefers large aromatic residues at S2' subsite and the exopeptidase activity prefers aromatic side chains in P2' position | Homo sapiens | ? | - |
? |  |
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Release 2023.1 (January 2023)
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