Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | activates | Capra hircus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-dipyridyl disulfide | - |
Capra hircus | |
antipain | - |
Capra hircus | |
Dimethylsulfoxide | - |
Capra hircus | |
Hg2+ | - |
Capra hircus | |
iodoacetamide | - |
Capra hircus | |
iodoacetic acid | - |
Capra hircus | |
L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane | E-64 | Capra hircus | |
leupeptin | - |
Capra hircus | |
Mg2+ | - |
Capra hircus | |
N-tosyl-lysyl chloromethylketone | - |
Capra hircus | |
N-tosyl-phenylalanine chloromethylketone | - |
Capra hircus | |
p-chloromercuribenzoate | - |
Capra hircus | |
Zn2+ | - |
Capra hircus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.09 | 0.29 | benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide | depending on concentration of dimethylsulfoxide, 1-2.5% | Capra hircus | |
0.51 | 2.36 | benzoyl-DL-Arg-beta-naphthylamide | depending on concentration of dimethylsulfoxide, 1-2.5% | Capra hircus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Capra hircus | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | 29000 | gel filtration, SDS-PAGE | Capra hircus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Proteins + H2O | Capra hircus | turnover of intracellular proteins | ? | - |
? | |
Proteins + H2O | Capra hircus | enzyme activation and conversion of precursor proteins to their active form | ? | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
dimethylsulfoxide | 50% of activity lost at 6% | Capra hircus |
dimethylsulfoxide | inhibits | Capra hircus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Capra hircus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | glycoprotein | Capra hircus |
Purification (Comment) | Organism |
---|---|
- |
Capra hircus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebrum | maximum activity in cerebrum | Capra hircus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
10 | - |
benzoyl-DL-Arg-beta-naphthylamide as substrate, in presence of 2.5% dimethylsulfoxide | Capra hircus |
40 | - |
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide as substrate, in presence of 2.5% dimethylsulfoxide | Capra hircus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-beta-naphthylamide + H2O | - |
Capra hircus | Arg + beta-naphthylamine | - |
? | |
benzoyl-DL-Arg-beta-naphthylamide + H2O | - |
Capra hircus | benzoyl-DL-Arg + beta-naphthylamine | - |
? | |
benzoyl-L-Arg-beta-naphthylamide + H2O | - |
Capra hircus | benzoyl-L-Arg + beta-naphthylamine | - |
? | |
benzoyl-L-Arg-p-nitroanilide + H2O | - |
Capra hircus | benzoyl-L-Arg + p-nitroaniline | - |
? | |
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O | - |
Capra hircus | benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine | - |
? | |
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O | - |
Capra hircus | benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine | - |
? | |
benzyloxycarbonyl-Arg-Arg-p-nitroanilide + H2O | - |
Capra hircus | benzyloxycarbonyl-Arg-Arg + p-nitroaniline | - |
? | |
benzyloxycarbonyl-Phe-Arg-4-methoxy-beta-naphthylamide + H2O | - |
Capra hircus | benzyloxycarbonyl-Phe-Arg + 4-methoxy-beta-naphthylamine | - |
? | |
benzyloxycarbonyl-Phe-Arg-p-nitroanilide + H2O | - |
Capra hircus | benzyloxycarbonyl-Phe-Arg + p-nitroaniline | - |
? | |
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O | - |
Capra hircus | ? + 4-methoxy-beta-naphthylamine | - |
? | |
Proteins + H2O | turnover of intracellular proteins | Capra hircus | ? | - |
? | |
Proteins + H2O | enzyme activation and conversion of precursor proteins to their active form | Capra hircus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
- |
Capra hircus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
fairly stable up to | Capra hircus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
4 | 6 | less stable below and above | Capra hircus |