Any feedback?
Literature summary for 3.4.21.B45 extracted from
- Major role of human KLK14 in seminal clot liquefaction (2008), J. Biol. Chem., 283, 19561-19569.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ACTG9 | synthetic inhibitor | Homo sapiens | |
| Zn2+ | semenogelins are able to reverse KLK14 inhibition by Zn2+ | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9P0G3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seminal plasma | KLK14 expression is significantly lower in individuals with clinically delayed liquefaction. Crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen | Homo sapiens | ? | - |
? | |
| semenogelin I + H2O | - |
Homo sapiens | ? | - |
? | |
| semenogelin II + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KLK14 | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
