Literature summary for 3.4.21.B41 extracted from

Lu, C.Y.; Hsieh, S.Y.; Lu, Y.J.; Wu, C.S.; Chen, L.C.; Lo, S.J.; Wu, C.T.; Chou, M.Y.; Huang, T.H.; Chang, Y.S.
Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma (2009), Genes Chromosomes Cancer, 48, 1057-1068.

Search for more literature for 3.4.21.B41

Application

Application	Comment	Organism
diagnostics	hypermethylated KLK10 is frequent in hepatocellular carcinoma and may be useful as marker for clinical application	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene KLK10, located at 19q13.3-q13.4, quantitative real-time PCR expression analysis, determination of DNA hypermethylation status of KLK10 in hepatocellular carcinoma cell lines and clinical samples, DNA methylation profiles, overview. Ectopic expression of KLK10 enhances drug sensitivity of HuH7 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
hepatocellular carcinoma cell	hypermethylated KLK10 is frequent in hepatocellular carcinoma	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-
J7 hepatoma cell	-	Homo sapiens	-
Mahlavu cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 10	-	Homo sapiens
KLK10	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	KLK10 hypermethylation is significantly associated with cirrhosis and HCV infection as well as inversely associated with HBV infection. Restoration of KLK10 expression, by 5-aza-cytidine treatment, reduces the ability of anchorage-independent growth, and sensitizes hepatocellular carcinoma cells to doxorubicin- or 5-fluorouracil-induced cytotoxicity	Homo sapiens

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Release 2023.1 (January 2023)